Job Description

The laboratory of Dr. Hui Zhang in the Division of Immunotherapy, Department of Surgery, and Brown Cancer Center at the University of Louisville School of Medicine is seeking a highly motivated and dedicated scientist for a Postdoctoral Research Fellow position.

Research in the Zhang Laboratory focuses on exploring the function of double-negative T (DN T) cells in antitumor immunity and cancer immunotherapy. DN T cells play a pivotal role in initiating antitumor immune responses and shaping the tumor microenvironment. Understanding the underlying mechanisms will enable the development of a novel paradigm for cancer immunotherapy. The successful candidate will play an integral role in advancing cutting-edge research funded by an NIH/NCI R01 grant.

Essential Duties and Responsibilities :

• Design and execute experiments related to DN T cells, tumor immunology, and cancer therapies, followed by data analysis.
• Draft manuscripts for publication and prepare presentations for scientific meetings.
• Assist in training and mentoring lab members, including graduate and undergraduate students, research interns, and technicians.
• Collaborate with other lab members to integrate data across multiple platforms.
• Maintain accurate and up-to-date experimental records.

Minimum Requirements :

• Ph.D. in Biomedical Sciences, such as Immunology, Cancer Biology, Cell Biology, or a related field.
• Extensive hands-on experience in molecular biology, cell biology, and immunology techniques.
• Proficiency in using animal models, flow cytometry, immunofluorescence, and in vitro bioassays.
• Strong skills in experimental design, data analysis, and troubleshooting.
• Ability to communicate research findings effectively in written and oral formats.

Preferred Qualifications :

• Extensive knowledge and expertise in bulk/single-cell RNA sequencing and bioinformatics.
• Knowledge of cancer immunotherapy, tumor microenvironment dynamics, and immune cell functions.

Competencies :

• Project planning and execution.
• Manuscript preparation of research findings.
• Statistical analysis, data interpretation and trouble shooting.
• Organized – manages time effectively, keeps tasks appropriately prioritized.
• Critical Thinking – ability to think through issues and identify appropriate options.
• Work Ethic – motivated, diligent, industrious, and persistent in the workplace, stays on tasks to completion, works at a pace sufficient to ensure optimal efficiency.
• Interpersonal – can build effective, strong working relationships with employees, colleagues, management and vendors through trust, communication, and credibility.
• Teamwork – ability to work with others.

Physical Requirements :

• Lab based environment:
• Occasionally: Works with poor ventilation or with regular exposure to odors,
• Occasional exposure to infectious material/diseases,
• Regular exposure to radiation, chemicals, solvents,
• Requires balancing to prevent falling or erratic movement,
• Light lifting or carrying 25 lbs. or less,
• Moderate lifting or carrying 26-50 lbs.
• Constantly: Normal office situation, Requires good near or distant vision.
• Requires distinguishing colors and/or depth perception to judge distances.
• Frequently: Typically sitting at a desk or table,
• Intermittently sitting, standing, stooping,
• Typically standing and/or walking.
• Requires handling by seizing, holding, grasping, or turning hands, but without finger dexterity, requires good hearing, requires feeling to perceive an object(s) size, shape, temperature, or texture by means of senses in your skin.

The above statements are intended to describe the general nature and level of work being performed by individuals assigned to this job. It is not intended to be an exhaustive list of all duties and responsibilities required of individuals in this job. Other duties may be assigned as determined by management. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential duties and responsibilities of this job.

Equal Employment Opportunity: The University of Louisville is an equal opportunity, affirmative action employer, and is committed to providing employment opportunities to all qualified applicants without regard to race, sex, age, color, national origin, ethnicity, creed, religion, disability, genetic information, sexual orientation, gender, gender identity and expression, marital status, pregnancy, or veteran status.

If you require assistance or accommodation with our application process due to an impairment or disability, please email the contact listed above directly, or reach out to the Employment team at employment@louisville.edu or 502.852.6258. Assistance and Accommodations Computers are available for application submission at the Human Resources Department located at 215 Central Avenue, Ste 205 - Louisville, Kentucky 40208.

About the University of Louisville In 2023, the University of Louisville celebrates its quasquicentennial, the 225th anniversary of the 1798 beginnings of higher education in Louisville. One of the nation’s first city-owned, public universities, UofL today is a vital ecosystem that creates thriving futures for students, our community and society. As one of only 79 universities in the United States to earn recognition by the Carnegie Foundation as both a Research 1 and a Community Engaged university, we impact lives in areas of student success and research and innovation, while our dynamic connection with our local and global communities provides unparalleled opportunities for students and citizens both. The university serves as an engine that powers Metro Louisville and the commonwealth and as a classroom for UofL’s more than 23,000 students, who benefit from partnerships with top employers and a wide range of community servic

opportunities. To learn more, visit louisville.edu. The University of Louisville is a public university in Louisville, Kentucky. It is a member of the Kentucky state university system.

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